With the advancement of technologies and growth of the economy, it is inevitable that more complex processes are deployed, producing more heterogeneous wastewater that comes from biomedical, biochemical and various biotechnological industries. While the conventional way of wastewater treatment could effectively reduce the chemical oxygen demand, pH and turbidity of wastewater, trace pollutants, specifically the endocrine disruptor compounds (EDCs) that exist in µg L�1 or ng L�1 have further hardened the detection and removal of these biochemical pollutants. Even in small amounts, EDC could interfere human�s hormone, causing severe implications on human body. Hence, this review elucidates the recent insights regarding the effectiveness of an advanced 2D material based on titanium carbide (Ti3C2Tx), also known as MXene, in detecting and removing EDCs. MXene�s highly tunable feature also allows its surface chemistry to be adjusted by adding chemicals with different functional groups to adsorb different kinds of EDCs for biochemical pollution mitigation. At the same time, the incorporation of MXene into sample matrices also further eases the analysis of trace pollutants down to ng L�1 levels, thereby making way for a more cleaner and comprehensive wastewater treatment. In that sense, this review also highlights the progress in synthesizing MXene from the conventional method to the more modern approaches, together with their respective key parameters. To further understand and attest to the efficacy of MXene, the limitations and current gaps of this potential agent are also accentuated, targeting to seek resolutions for a more sustainable application. © The Author(s), under exclusive licence to Springer Nature B.V. 2024.