This study presents utilization of multiple data-driven models for predicting CO2 minimum miscibility pressure (MMP). The aim is to address the issue of existing models lacking explicit presentation. With a database of 155 data points, five models were developed using artificial neural network (ANN), multigene genetic programming (MGGP), support vector regression (SVR), multivariate adaptive regression splines (MARS), and multiple linear regression (MLR). Comparative analysis was conducted using statistical metrics (R2, MSE, MAE, RMSE), and sensitivity analysis was performed on input variables. The results showed that ANN and SVR had comparable predictive performance (ANN: R2 = 0.982, MSE = 0.00676, MAE = 0.9765, RMSE = 0.082), SVR (R2 = 0.935, MSE = 0.0041, MAE = 0.72, RMSE = 0.064) followed by MARS, MLR, and MGGP. Sensitivity analysis revealed that reservoir temperature was the most influential parameter across all models, except for the MLR algorithm where injected CO2 amount was crucial. These models can be used for a wide range of CO2 MMP ranging from 940 psi to 5830 psi, thus rendering them useful for any reservoir globally. These models offer improved accuracy and computational efficiency compared to existing ones, potentially reducing costs associated with laboratory experiments and providing rapid and precise CO2 MMP predictions. © 2024 Institution of Chemical Engineers