Ubiquitous communication networks is a keystone for New Generation Network (NWGN). Mobile Wireless Communication Networks (MWSN) is a viable solution to accomplish the requirements of NWGN. Due to mobility of sensor nodes, the data reliability and end-to-end delay with energy efficiency in the network is an enormous concern. Various real-time and delay sensitive applications enforced to use both environments mobile and fixed sensor nodes, whereas the others claims an entire mobile sensors environments in network. Packet loss ratio and end-to-end delay happened because of the nodes mobility which is directly impact to degrade the quality of service, network lifetime and energy consumption. This paper enlightens a comprehensive comparison between single and multi hop inter-cluster routing strategy from cluster head to base station. Moreover, the performance of multi hop routing is calculated and compared with single hop LEACH routing strategy. The simulation results reveal that multi hop routing strategy is to increase the sensor nodes throughput and network lifetime but not efficient approach for delay sensitive and data reliable applications. © 2011 IEEE.