2-Octylcyclopentanone Inhibits Beta Lactam Resistant Diabetic Wound Pathogens

Rozman, N.A.S. and Yenn, T.W. and Ring, L.C. and Rashid, S.A. and Wen-Nee, T. and Lim, J.W. (2023) 2-Octylcyclopentanone Inhibits Beta Lactam Resistant Diabetic Wound Pathogens. Tropical Life Sciences Research, 34 (1). pp. 279-291.

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Abstract

Microbial infection is a frequent complication of diabetic foot ulcers, with up to 82 of ulcers being infected at the initial stage of diabetes. Furthermore, the emergence of beta lactam resistant pathogens managed to eliminate the use of beta lactam antibiotics as a chemotherapeutic alternative. This further increases the amputation and mortality rate. Hence, the aim of this study is to evaluate antimicrobial efficacy of a ketone derivative 2-octylcyclopentanone against diabetic wound pathogens. The inhibitory activity of the compound was determined using disc diffusion and broth microdilution assay. Generally, 2-octylcyclopentanone showed broad-spectrum antimicrobial activity, particularly against beta lactam resistant pathogens. The compound showed comparably better antimicrobial activity than all reference antibiotics, including chloramphenicol, streptomycin, ampicillin and penicillin. In addition, the same compound also inhibits a clinically isolated Pseudonomas aeruginosa that was resistant to all reference antibiotics. The activity was microbicidal based on the low minimal lethality concentration recorded, particularly on MRSA, P. aeruginosa and Candida utilis. The killing efficiency of the compound was concentration dependent. During kill curve analysis, the inhibitory activity of 2-octylcyclopentanone was concentration and time-dependent. 99.9 of reduction of bacterial growth was observed. MRSA and P. aeruginosa, two significant diabetic wound infections, are totally inhibited by the molecule at a concentration of minimum lethality concentration. In short, 2-octylcyclopentanone exhibited significant inhibitory towards wide range of diabetic wound pathogens. Which is considered crucial since it will provide a safe and effective alternative treatment for diabetic ulcer infection. © Penerbit Universiti Sains Malaysia, 2023.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: antibiotics; antimicrobial activity; chemical compound; concentration (composition); diabetes; inhibition; injury; mortality; pathogen
Depositing User: Mr Ahmad Suhairi UTP
Date Deposited: 04 Jun 2024 14:11
Last Modified: 04 Jun 2024 14:11
URI: https://khub.utp.edu.my/scholars/id/eprint/19308

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