The water resource crisis and concerns with environmental pollution prompt the necessity to upgrade conventional wastewater treatment processes. The microalgae-based wastewater treatment process has shown many advantages that can fulfill the stricter demands for improved wastewater treatment. Microalgae cultivation can be carried out in different photobioreactors and under different operational conditions. The cultivation of the microalgae biomass provides the bioremediation of some targeted pollutants through uptake/digestion or biosorption, resulting in treated effluent and the production of biomass. This paper reviews the progress in microalgae-biotechnology for industrial wastewater treatment. A brief overview of microalga types/classification, the cultivation photobioreactors type, and conditions was first provided. Next, a comprehensive review of the bioremediation of industrial wastewater, including distillery, heavy metals, textiles, and emerging contaminants, was provided. Finally, perspectives on the potential scale-up of the technology and some critical considerations were also discussed. © 2023 by the authors.