3La-10Co/Al2O3 catalyst was synthesized and catalytically optimized by using response surface methodology (RSM) for ethylene glycol dry reforming (EGDR). 3La-10Co/Al2O3 showed excellent EGDR, whereby optimum performance (EG conversion of 80.43 , CO2 conversion of 42.51 , H2 yield of 76.41 , and CO yield of 71.77 ) was attained under moderate reaction conditions (998 K, CO2 partial pressure of 15 kPa, and EG partial pressure of 23 kPa). The RSM model was statistically significant, and validation experiments showed a negligible discrepancy between the experimental and predicted values, demonstrating the validity and dependability of the model. The stability and regeneration studies evidenced the feasibility and catalytic stability of 3La-10Co/Al2O3. © 2023 Wiley-VCH GmbH.