The exclusion of salt from brine or produce water in the presence of hydrates is a potentials technique to produce clean water and treat produce water. However, the effect of water content on the salt exclusion efficiency is needed to provide relevant data to optimize the technology. In this work, NaCl removal efficiency in CO2 hydrate system was evaluated at varying water volumes in 2 wt NaCl solution. The experiments were carried out at a fixed pressure of 30 bar in various water volumes of feed ranging from 200 ml to 500 ml to find out the optimum feed conditions at 2 °C. The parameters evaluated are moles of gas consumed, water recovery and removal efficiency. It was found that with increasing water volume from 300 ml to 500 ml the removal efficiency increased from 30.83 to 60.08 at 3.5 MPa. Averagely, the water volume of 500 ml produced the highest water recovery (58.6) and removal efficiency (41.17) at all the pressures (2.5 MPa�3.5 MPa). The findings from this research will lead to the design of an efficient reactor for commercialization of the hydrate-based desalination system. © 2021