In this study, the removal performance of bisphenol A (BPA) from synthetic wastewater using the forward osmosis method was compared between polyamide thin film composite membrane (PA-TFC) and polysulfone (PSf) membrane substrate. The thin-film composite membrane was prepared by using flat polysulfone (PSf) sheets as membrane substrate through in-situ interfacial polymerization technique. To generate the thin film surface on the PSf substrate, M-phenylenediamine (MPD) and 1,3,5-benzene trichloride (TMC) were utilized as monomers in aqueous and organic solutions, respectively. The BPA retention efficiency of the PSf and TFC membranes was examined and compared accordingly. The membranes were characterized by using atomic force microscopy (AFM), field emission scanning electron microscope (FESEM), Fourier transform infrared spectroscopy (FTIR), and contact angle analysis. The fabricated thin film on the PSf substrate membrane has enhanced its hydrophilicity which aids in wastewater treatment by increasing the membrane�s water flow rate. A synthetic BPA wastewater solution of 100 mgL-1 was prepared to evaluate the performance of the membrane. Based on the finding of this study, the PSf substrate and PA-TFC membrane yielded 25 and 91 of BPA removal from the feed solution, respectively. © 2022, Malaysian Society of Analytical Sciences. All rights reserved.