Mitigation of wax deposition is of major interest, especially in the oil and gas industry, to minimize the flow assurance and production problems. In view of financial savings, the currently established method still has more opportunities to improve, particularly in a green technology sector in compliance with a stringent environmental policy. Therefore, a cost-efficient and environmentally friendly alternative method is required in handling waxy crude oil. This paper describes the investigation of Fatty Acid Methyl Ester (FAME) as a waxy crude oil flow improver via changes in wax particles' growth and aggregation rate through molecular dynamics simulation using Biovia Materials Studio. The molecular dynamics simulation shows an increase in the wax molecules' interaction energy from an average of 851 kcal/mol to 972 kcal/mol. Similarly, kinetic energy increases from an average of 629 kcal/mol to 675 kcal/mol. The mean square displacement also increases from 3.195 angstrom2 to 6.007 angstrom2. There is also an increase in the radial distribution function by having a higher probability of finding particles in the presence of FAME. The results indicate that FAME reduces the wax particles' growth and aggregation rate, mitigating the wax depositions and improving the waxy crude oil flow. Copyright © 2022, AIDIC Servizi S.r.l.