A comprehensive series of experiments on foaming of two (2) types of crude oil and four (4) types of synthesized Gemini silicone- amine base defoamer in simulated produced water system containing foam surfactant Foam Assisted-Water Alternating Gas (FAWAG) package were investigated under the influence of column temperature at 30-60 °C, applied pressure of 1-4 bar, and fixed fluid flowrate of 0.5 L/min. In this study, the presence of high saturates composition in the crude oil which at 45-75.8 influence the foam stability of the fluids. This reflects the waxy types of crude oils with higher density properties of 0.8768-0.858 Kg/L and increase concentration of foam surfactant from 30 to 90 in the produced water system influences the foaming stability. The microscopic observation shows that bigger bubble size about the average of 400-500 µm would slows down the liquid drainage, resulting in foam stability behavior. Defoamers with various structures ranged from amine short-chain, amine long-chain, amine branched-chain and amide-chain were analysed to determine the effect of molecular structure at various concentration from 5-40ppm. The defoaming ability was determined by foam height and collapse time. The amide short-chain and amine branched -chain had excellent foam breaking performance which was observed from the mean bubble size reduction to 50-100 µm resulting from formation of unstable bridge across lamellae causing the foam to rupture, allowing faster liquid drainage, thus improving suppression performance. Copyright © 2022, Offshore Technology Conference.