Workplace hazards can have a significant influence on a worker�s physical and mental health, reducing an organization�s effectiveness in terms of safety. However, psychosocial hazards are being recognized as a crucial component that must be addressed for the individual�s and organization�s safety. The purpose of this research was to propose and statistically evaluate a brief theoretical framework based on leadership, organizational communication, work environment, and psychosocial hazards in Malaysia�s upstream oil and gas sector. The framework was tested on 380 Malaysian upstream oil and gas workers. The collected data were analyzed using partial least squares and structural equation modelling (PLS-SEM). The study�s findings revealed that in the Malaysian oil and gas industry, leadership, communication, and work environment negatively influenced the psychosocial hazards. This negative association between predictors and psychosocial hazards, particularly job expectations, control, role, and relationships, indicates new grounds for research. It is discussed how the findings could be used to track employees� well-being over time and generate focused treatments. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.