This chapter presents a brief overview of recent research activities based on different reactor designs and hydrate formers implemented to enhance hydrate-based desalination technology. The literature on hydrate-based desalination is thoroughly reviewed with an emphasis on experimental developments based on different reactor designs, various hydrate formers that affect hydrate formation thermodynamics and enhances the kinetics of hydrate formation. Aside from that, effect of various porous media and its influence in improving the hydrate promotion is discussed. © 2022 John Wiley & Sons, Inc.