This chapter summarizes the techno-economical aspect of conventional desalination technologies. As the total energy required and the efficiency of the process are the main parameters to decide the system for commercialization hence these calcualtions are performed and determined by a detailed energy analysis for conventional methods and hydrate based desalaintion. It focuses mainly on the minimization of energy usage and the water-energy-nexus of conventional and as well as gas hydrate technology. © 2022 John Wiley & Sons, Inc.