Global climate change has increased severe torrential hazards, particularly debris flows in mountainous regions. After floods and earthquakes, debris flows are the most devastating natural hazard in the world. The effects of debris flow on human life and built environments necessitate reconsidering current infrastructure planning, engineering, and risk management practices. Hence, the vulnerability of elements at risk is critical for effective risk reduction systems. Therefore, this article reviews the existing physical vulnerability approach of infrastructure, particularly building toward debris flow hazards in the last 20 years. Furthermore, uncertainties associated with the vulnerability assessment and their quantification techniques have also been discussed in detail. It was found that matrices, curves, and indicators have been extensively used for vulnerability assessment approaches in the last two decades. However, if aleatory and epistemic uncertainties are not quantified or conserved in the vulnerability assessment process, it makes the system inefficient and unreliable. Moreover, data requirements, strengths, and weaknesses of approaches presented herein are highlighted with case studies. Finally, a thorough discussion on future needs in the field of risk assessment methodologies is highlighted by considering uncertainties into account. © 2022 by the authors.