CO2 is the leading anthropogenic greenhouse gas (GHG) responsible for global warming. Mitigating the effect of anthropogenic CO2 emission is among the priority. As Malaysia is one of the largest CO2 emitters among the four ASEAN countries, identifying a potential geological formation for CO2 storage is compulsory in order to minimize the environmental effect of emitted CO2. Hence, fundamental research in which fluid-rock interaction of Paleogene basalt samples was assessed in the context of Malaysia�s need to identify any potential host rock for mineral carbonation. For this purpose, laboratory experiments were conducted, including CO2 injection using high pressure and high temperature (HPHT) reactor, geochemical analysis on water samples (leachates) using atomic absorption spectroscopy (AAS), and mineralogical analysis on the reacted rock samples using X-Ray Diffraction (XRD) techniques. During the fluid-rock interaction experiment, the water chemistry and mineralogical changes in the rock samples were evaluated at 914 psi and 3133 psi pressures and 100oC and 120oC temperature conditions. The concentration of Ca, Mg, and Fe released into the solution increased when the pressure of CO2 applied increased. Yet, the concentration of these elements showed a non- consistent trend with the rise of the experimental temperature. These results were influenced by the reaction of silicate and carbonate minerals during the experiment. This finding may provide clues into the pressure and temperature values required for geological CO2 sequestration in the Malaysian geological settings. © 2021. All rights reserved.