The ISO standards have been traditionally used in the business context, specifically in manufacturing and services, to provide a framework for total quality management. Such application has now been found in the context of higher education; thus, this paper aims to look into the implementation of ISO standards in the management of a private university in Vietnam. Using a desk research approach, the study seeks to detail the application of ISO in the areas of educational support system and business operation system in the strategic management of this institution, showing the quantitative operational results that have been achieved in all aspects of HR management, teaching quality, new enrollment number and financial growth. © 2021 by the authors.