Inclusion Complexes of β-Cyclodextrin/Pioglitazone and β-Cyclodextrin-Ionic Liquid/Pioglitazone: Spectroscopic Methods Combined with Molecular Docking Studies

Rahim, N.Y. and Md Zuki, N.N. and Jumbri, K. and Mohamad, S. and Abdul Manan, N.S. and Sidek, N. and Boon, Y.H. and Ramachandran, M.R. (2021) Inclusion Complexes of β-Cyclodextrin/Pioglitazone and β-Cyclodextrin-Ionic Liquid/Pioglitazone: Spectroscopic Methods Combined with Molecular Docking Studies. In: UNSPECIFIED.

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Abstract

The complexes of β-cyclodextrin/pioglitazone and β-cyclodextrin-ionic liquid/pioglitazone were prepared by kneading method. Characterization using FT-IR, thermogravimetric analysis and NMR had proven the formation of the complexes. From 1H NMR determination, pioglitazone is proven to form hydrogen bonding and inclusion complex with native β-cyclodextrin and β-cyclodextrin-ionic liquid. The molecular docking also reveals the same interaction involved for the formation of complexes β-cyclodextrin/pioglitazone and β-cyclodextrin-ionic liquid/pioglitazone. The binding energy obtained from molecular studies for the complex of β-cyclodextrin-ionic liquid/pioglitazone is higher than the binding energy of β-cyclodextrin/pioglitazone. © 2021, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Additional Information: cited By 0; Conference of 6th International Conference on Fundamental and Applied Sciences, ICFAS 2020 ; Conference Date: 13 July 2021 Through 15 July 2021; Conference Code:270909
Depositing User: Mr Ahmad Suhairi UTP
Date Deposited: 10 Nov 2023 03:30
Last Modified: 10 Nov 2023 03:30
URI: https://khub.utp.edu.my/scholars/id/eprint/15549

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