This paper presents a preliminary study of the multi-solvent effect on the formation of cellulose acetate nanofibre through the electrospinning method. Due to cellulose acetate nanofibre's potential application in various fields, a different solvent was suggested to produce consistent quality of cellulose acetate nanofibre. The solvent utilised in the study were acetone and water, while ethanol was added to the formulation. An attempt to add ethanol to acetone/water mix-solvent was performed to determine whether the tri-solvent technique could produce the nanofibre. The produced nanofibre was characterised using SEM to study the nanofibre morphology. The tri-solvent approach efficiently produced cellulose acetate nanofibre with relatively low electrostatic field strength (EFS) with non-beaded nanofibre. © 2021 International Scientific Organization. All Rights Reserved.