Molybdenum disulphide/cellulose acetate nanofiber composite on screen printed electrodes for detecting cardiac troponin by electrical impedance spectroscopy

Gobalu, K. and Vasudevan, M. and Gopinath, S.C.B. and Perumal, V. and Ovinis, M. (2021) Molybdenum disulphide/cellulose acetate nanofiber composite on screen printed electrodes for detecting cardiac troponin by electrical impedance spectroscopy. Cellulose, 28 (9). pp. 5761-5774. ISSN 09690239

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Abstract

Elevated levels of Troponin I, a cardiac biomarker, is indicative of an Acute Myocardial Infarction. However, current immunosensing methods to detect the presence of Troponin I such as Enzyme-Linked Immunosorbent Assay (ELISAs) has poor detection accuracy and unreliable quantitative results due to its single model readout. On the other hand, impedance spectroscopy detection using aptamer-modified electrodes is a more reliable and robust detection method, with higher sensitivity and better selectivity. In this paper, we propose a molybdenum disulphide/cellulose acetate (MoS2/CA) nanofiber composite on screen printed electrodes for detecting troponin I by Electrical Impedance Spectroscopy. The MoS2/CA nanofiber was electrospin at various amount of MoS2 nanosheets (0.025 g, 0.05 g, 0.1 g and 0.2 g). Morphological, structural and optical characterization was conducted to discover the functional group as well as crystallinity formed in the MoS2/CA composite nanofiber. The developed electrochemical nano-biosensor can detect up to 10 fM of Troponin I with 90 stability after 6 weeks, ~ 5 folds improvement compared to other proteins (selectivity), 0.89 µA mM�1 cm� 2 sensitivity of sensor and RSD value of 3.8 (repeatability). © 2021, The Author(s), under exclusive licence to Springer Nature B.V.

Item Type: Article
Additional Information: cited By 17
Uncontrolled Keywords: Composite structures; Crystallinity; Electric impedance; Electric impedance measurement; Electrodes; Layered semiconductors; Molybdenum metallography; Nanofibers; Spectroscopy; Sulfur compounds; Volatile fatty acids, Acute myocardial infarction; Electrical impedance spectroscopy; Enzyme linked immunosorbent assay; Immunosensing methods; Impedance spectroscopy; Molybdenum disulphide; Screen printed electrodes; Structural and optical characterizations, Molybdenum compounds, Crystallinity; Electric Impedance; Electrodes; Molybdenum Compounds; Spectroscopy; Sulfur Compounds
Depositing User: Mr Ahmad Suhairi UTP
Date Deposited: 10 Nov 2023 03:29
Last Modified: 10 Nov 2023 03:29
URI: https://khub.utp.edu.my/scholars/id/eprint/14875

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