Gobalu, K. and Vasudevan, M. and Gopinath, S.C.B. and Perumal, V. and Ovinis, M. (2021) Molybdenum disulphide/cellulose acetate nanofiber composite on screen printed electrodes for detecting cardiac troponin by electrical impedance spectroscopy. Cellulose, 28 (9). pp. 5761-5774. ISSN 09690239
Full text not available from this repository.Abstract
Elevated levels of Troponin I, a cardiac biomarker, is indicative of an Acute Myocardial Infarction. However, current immunosensing methods to detect the presence of Troponin I such as Enzyme-Linked Immunosorbent Assay (ELISAs) has poor detection accuracy and unreliable quantitative results due to its single model readout. On the other hand, impedance spectroscopy detection using aptamer-modified electrodes is a more reliable and robust detection method, with higher sensitivity and better selectivity. In this paper, we propose a molybdenum disulphide/cellulose acetate (MoS2/CA) nanofiber composite on screen printed electrodes for detecting troponin I by Electrical Impedance Spectroscopy. The MoS2/CA nanofiber was electrospin at various amount of MoS2 nanosheets (0.025 g, 0.05 g, 0.1 g and 0.2 g). Morphological, structural and optical characterization was conducted to discover the functional group as well as crystallinity formed in the MoS2/CA composite nanofiber. The developed electrochemical nano-biosensor can detect up to 10 fM of Troponin I with 90 stability after 6 weeks, ~ 5 folds improvement compared to other proteins (selectivity), 0.89 µA mM�1 cm� 2 sensitivity of sensor and RSD value of 3.8 (repeatability). © 2021, The Author(s), under exclusive licence to Springer Nature B.V.
Item Type: | Article |
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Additional Information: | cited By 17 |
Uncontrolled Keywords: | Composite structures; Crystallinity; Electric impedance; Electric impedance measurement; Electrodes; Layered semiconductors; Molybdenum metallography; Nanofibers; Spectroscopy; Sulfur compounds; Volatile fatty acids, Acute myocardial infarction; Electrical impedance spectroscopy; Enzyme linked immunosorbent assay; Immunosensing methods; Impedance spectroscopy; Molybdenum disulphide; Screen printed electrodes; Structural and optical characterizations, Molybdenum compounds, Crystallinity; Electric Impedance; Electrodes; Molybdenum Compounds; Spectroscopy; Sulfur Compounds |
Depositing User: | Mr Ahmad Suhairi UTP |
Date Deposited: | 10 Nov 2023 03:29 |
Last Modified: | 10 Nov 2023 03:29 |
URI: | https://khub.utp.edu.my/scholars/id/eprint/14875 |