This paper presents an experimental and modeling studies on the thermodynamic inhibition effects of the mixture of monoethlyene glycol (MEG) and glycine (Gly) on the carbon dioxide hydrate phase boundary condition. The monoethlyene glycol and glycine (1:1) mixture inhibition effects were investigated at concentrations of 5, 10, and 15 wt. and pressure ranges from 2.0�4.0 MPa. The effects of the proposed mixture on the carbon dioxide hydrate phase boundary were evaluated by measuring the dissociation temperature of carbon dioxide hydrate using a T-cycle method. The synergistic effect was evaluated based on comparison with pure MEG and Gly data. The results show that 15 wt. of MEG and Gly mixture displays the highest inhibition effect compared to the 5 and 10 wt. mixtures, respectively. However, the synergistic effect is higher at 10 wt.. Dickens' model was also adopted to predict the phase equilibrium data of CO2 hydrates in the presence of the mixture. The modified model successfully predicted the data within a maximum error of ± 0.52 K. © 2021, The Author(s).