Metal organic framework (MOF) is a recent class of porous materials that are built from metal cluster and organic linker. Among the discovered MOFs, UiO-66 has demonstrated both attributes of water stability and hydrophilic, making it suitable for wastewater treatment. In this study, 0.5 wt UiO-66 was integrated into polysulfone membrane as nanofiller to form mixed-matrix membrane (MMM) with a thin-film composite, dense polyamide layer formed on top of the substrate layer that intended to remove 100 ppm of arsenic V from wastewater through forward osmosis. The successful synthetization of UiO-66 nanoparticle was proven by XRD and FESEM. The pure water permeability was significantly higher with the presence of LiCl in dope solution as pore former. It was found that the arsenic rejection achieved was 87.5 with satisfactory water flux and salt reverse flux. © 2020 Penerbit UTM Press. All rights reserved