MicroRNA-155 complementation on a chemically functionalized dual electrode surface for determining breast cancer

Gopinath, S.C.B. and Perumal, V. and Xuan, S. (2020) MicroRNA-155 complementation on a chemically functionalized dual electrode surface for determining breast cancer. 3 Biotech, 10 (6). ISSN 2190572X

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Abstract

This study correlated and quantified the expression of microRNA-155 with breast cancer to determine breast cancer progression. The target microRNA-155 sequence was identified by complementation on a capture-probe sequence-immobilized interdigitated dual electrode surface. The sensitivity was found to be 1 fM, and the limit of detection fell between 1 and 10 fM. The specific sequence selectivity with single mismatches, triple mismatches, and noncomplementary bases failed to complement the capture-probe sequence. The obtained results demonstrate the selective determination of the microRNA-155 sequence and can help to diagnose breast cancer. © 2020, King Abdulaziz City for Science and Technology.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: ethanolamine; microRNA 155; streptavidin, Article; breast cancer; cancer diagnosis; cancer growth; chemical interaction; female; gene expression; gene identification; gene targeting; genetic complementation; human; limit of detection; priority journal; RNA sequence
Depositing User: Mr Ahmad Suhairi UTP
Date Deposited: 10 Nov 2023 03:27
Last Modified: 10 Nov 2023 03:27
URI: https://khub.utp.edu.my/scholars/id/eprint/13108

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