Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity

Chowdhury, M.R. and Moshikur, R.M. and Wakabayashi, R. and Tahara, Y. and Kamiya, N. and Moniruzzaman, M. and Goto, M. (2019) Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity. Chemical Communications, 55 (54). pp. 7737-7740. ISSN 13597345

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Abstract

We report a one-step emulsification and rapid freeze-drying process to develop a curcumin-ionic liquid (CCM-IL) complex that could be readily dispersed in water with a significantly enhanced solubility of �8 mg mL-1 and half-life (t1/2) of �260 min compared with free CCM (solubility �30 nM and t1/2 � 20 min). This process using an IL consisting of a long chain carbon backbone as a surfactant, may provide an alternative way of enhancing the solubility of poorly water-soluble drugs. © 2019 The Royal Society of Chemistry.

Item Type: Article
Additional Information: cited By 42
Uncontrolled Keywords: carbon; curcumin; ionic liquid; water, Article; chemical structure; concentration (parameter); controlled study; drug solubility; emulsion; freeze drying; process development; solubility
Depositing User: Mr Ahmad Suhairi UTP
Date Deposited: 10 Nov 2023 03:26
Last Modified: 10 Nov 2023 03:26
URI: https://khub.utp.edu.my/scholars/id/eprint/12124

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