One of the main security issues in mobile ad hoc networks (MANETs) is a malicious node that can falsify a route advertisement, overwhelm traffic without forwarding it, help to forward corrupted data and inject false or uncompleted information, and many other security problems. Mapping immune system mechanisms to networking security is the main objective of this paper which may significantly contribute in securing MANETs. In a step for providing secured and reliable broadband services, formal specification logic along with a novel immuneinspired security framework (I2MANETs) are introduced. The different immune components are synchronized with the framework through an agent that has the ability to replicate, monitor, detect, classify, and block/isolate the corrupted packets and/or nodes in a federated domain. The framework functions as the Human Immune System in first response, second response, adaptability, distributability, and survivability and other immune features and properties. Interoperability with different routing protocols is considered. The framework has been implemented in a real environment. Desired and achieved results are presented. © 2010 ACM.