This paper presents the design and development of an expert system (ES) for Islamic medication on a mobile platform. This ES can be accessed by users via mobile devices to obtain treatment or therapy to cure illnesses based on the verses of Al-Quran and the Prophetic sayings (Hadith). The mobile platform allows users to access the ES almost anywhere and anytime when the situation is deemed necessary. The knowledge base in the ES is intended to exhaustively compile the types of illnesses/sicknesses with their related cures or treatments from Quran and/or Hadith. The Mobile Islamic Medication Expert System (MIMES) was developed with the aim to preserve the diminishing Islamic medical practices among the younger generations. © 2010 IEEE.