Increasing global population intensifies the food demand pressure while meeting the increasing environmental legislation. To cater for such demand, agriculture sector shifts for mass food production accompanied with the use of a large amount of agrochemicals such as fertilizers, pesticides, antibiotics, and growth hormones. As a result, these agrochemicals' residues pollute the ecosystem and environment through surface runoff. It has been a great challenge in treating agricultural runoff due to its contaminant loadings and wide variability of different compounds in the wastewater to meet the stringent standards in an economically feasible manner. This chapter delineates the current state-of-the-art of wastewater treatment methods for agricultural runoff. © 2020 by IGI Global. All rights reserved.