In general, small and medium enterprise (SME) business face substantially greater risks in Information Communication and Technology (ICT) implementation than large businesses do because of inadequate resources and limited education about ICT. There are many differences that exist between large companies and SME organizations in relation to adoption of ICT. To date, the SME clinics in general have not been convinced of the benefit of ICT. SME clinics utilize computerized system in supporting their businesses are still minimum and paper-based practices are still the norm. Hence, the objective of this paper is to report on the literature study related to identification of technology resistance and acceptance factors of ICT utilization in an organizations and study of any existing prominent theoretical frameworks on Information System (IS) Success Model. The study then outlines the proposed conceptual Success Model for SME Clinics Information System. © 2010 IEEE.