The purpose of the current research is to investigate the computational heat transfer coefficients of SiO2 nanoparticles dispersed in ethylene glycol (EG) and water (W) mixtures in 60:40 (60EGW) and 40:60 (40EGW) by volume and evaluate the influence of base fluid. The thermophysical properties of SiO2, based nanoparticles dispersed in 60EGW and 40EGW base fluid were taken from available literature and regression analysis was performed for formulating equations. The theoretical data was used as input in computational analysis for the investigation of heat transfer coefficients. The results indicate that the heat transfer coefficients for SiO2/60EGW and SiO2/40EGW based nanofluids have shown an enhancement of 25 and 55 respectively when compared with base fluids. Hence, it can be concluded that SiO2/40EGW nanofluids show a better heat transfer rates than SiO2/60EGW nanofluids. © 2018 Lavoisier