NO^● Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis

by Karolina Mikulska-Ruminska, Tamil S. Anthonymuthu, Anastasia Levkina, Indira H. Shrivastava, Alexandr A. Kapralov, Hülya Bayır, Valerian E. Kagan, Ivet Bahar
Published 2021-05-01

Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure

by Kavita Vats, Oleg Kruglov, Alicia Mizes, Svetlana N. Samovich, Andrew A. Amoscato, Vladimir A. Tyurin, Yulia Y. Tyurina, Valerian E. Kagan, Yuri L. Bunimovich
Published 2021-11-01

Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators

by Joel S Greenberger, David eClump, Valerian eKagan, Hulya eBayir, John S Lazo, Peter eWipf, Song eLi, Xiang eGao, Michael Wayne Epperly
Published 2012-01-01

Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes

by Sehwan Jang, Xavier R. Chapa-Dubocq, Yulia Y. Tyurina, Claudette M. St Croix, Alexandr A. Kapralov, Vladimir A. Tyurin, Hülya Bayır, Valerian E. Kagan, Sabzali Javadov
Published 2021-09-01

2357 Lost and found: Detection of brain cardiolipins in plasma after cardiac arrest

by Andrew M. Lamade, Tamil S. Anthonymuthu, Elizabeth M. Kenny, Hitesh Gidwani, Nicholas M. Krehel, Andrew A. Amoscato, Adam C. Straub, Valerian E. Kagan, Cameron Dezfulian, Hülya Bayır
Published 2018-06-01

The lipase cofactor CGI58 controls placental lipolysis

by Jennifer Guerrero-Santoro, Mayumi Morizane, Soo-Young Oh, Takuya Mishima, Julie P. Goff, Ibrahim Bildirici, Elena Sadovsky, Yingshi Ouyang, Vladimir A. Tyurin, Yulia Y. Tyurina, Valerian E. Kagan, Yoel Sadovsky
Published 2023-05-01

A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO• sabotage of theft-ferroptosis

by Haider H. Dar, Tamil S. Anthonymuthu, Liubov A. Ponomareva, Austin B. Souryavong, Galina V. Shurin, Alexandr O. Kapralov, Vladimir A. Tyurin, Janet S. Lee, Rama K. Mallampalli, Sally E. Wenzel, Hülya Bayir, Valerian E. Kagan
Published 2021-09-01

Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production

by Oleg Kruglov, Kavita Vats, Vishal Soman, Vladimir A. Tyurin, Yulia Y. Tyurina, Jiefei Wang, Li’an Williams, Jiying Zhang, Cara Donahue Carey, Erik Jaklitsch, Uma R. Chandran, Hülya Bayir, Valerian E. Kagan, Yuri L. Bunimovich
Published 2023-12-01

Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

by Nicholas F. Fitz, Kyong Nyon Nam, Cody M. Wolfe, Florent Letronne, Brittany E. Playso, Bistra E. Iordanova, Takashi D. Y. Kozai, Richard J. Biedrzycki, Valerian E. Kagan, Yulia Y. Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamova
Published 2021-06-01

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

by Krishnendu Chakraborty, Mahesh Raundhal, Bill B. Chen, Christina Morse, Yulia Y. Tyurina, Anupriya Khare, Timothy B. Oriss, Rachael Huff, Janet S. Lee, Claudette M. St. Croix, Simon Watkins, Rama K. Mallampalli, Valerian E. Kagan, Anuradha Ray, Prabir Ray
Published 2017-01-01

Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury

by Zhongyuan Bao, Yinlong Liu, Binglin Chen, Zong Miao, Yiming Tu, Chong Li, Honglu Chao, Yangfan Ye, Xiupeng Xu, Guangchi Sun, Pengzhan Zhao, Ning Liu, Yan Liu, Xiaoming Wang, Sin Man Lam, Valerian E. Kagan, Hülya Bayır, Jing Ji
Published 2021-07-01

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

by Alexander Beatty, Tanu Singh, Yulia Y. Tyurina, Vladimir A. Tyurin, Svetlana Samovich, Emmanuelle Nicolas, Kristen Maslar, Yan Zhou, Kathy Q. Cai, Yinfei Tan, Sebastian Doll, Marcus Conrad, Aravind Subramanian, Hülya Bayır, Valerian E. Kagan, Ulrike Rennefahrt, Jeffrey R. Peterson
Published 2021-04-01

Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo

by Yulia Y. Tyurina, Alexandr A. Kapralov, Vladimir A. Tyurin, Galina Shurin, Andrew A. Amoscato, Dhivyaa Rajasundaram, Hua Tian, Yuri L. Bunimovich, Yulia Nefedova, William G. Herrick, Ralph E. Parchment, James H. Doroshow, Hulya Bayir, Apurva K. Srivastava, Valerian E. Kagan
Published 2023-05-01

Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure

by Sudipta Das, Tomasz W. Kaminski, Brent T. Schlegel, William Bain, Sanmei Hu, Akruti Patel, Sagar L. Kale, Kong Chen, Janet S. Lee, Rama K. Mallampalli, Valerian E. Kagan, Dhivyaa Rajasundaram, Bryan J. McVerry, Prithu Sundd, Georgios D. Kitsios, Anuradha Ray, Prabir Ray
Published 2024-06-01

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

by Filippo Veglia, Vladimir A. Tyurin, Dariush Mohammadyani, Maria Blasi, Elizabeth K. Duperret, Laxminarasimha Donthireddy, Ayumi Hashimoto, Alexandr Kapralov, Andrew Amoscato, Roberto Angelini, Sima Patel, Kevin Alicea-Torres, David Weiner, Maureen E. Murphy, Judith Klein-Seetharaman, Esteban Celis, Valerian E. Kagan, Dmitry I. Gabrilovich
Published 2017-12-01

15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation

by Tadao Nagasaki, Alexander J. Schuyler, Jinming Zhao, Svetlana N. Samovich, Kazuhiro Yamada, Yanhan Deng, Scott P. Ginebaugh, Stephanie A. Christenson, Prescott G. Woodruff, John V. Fahy, John B. Trudeau, Detcho Stoyanovsky, Anuradha Ray, Yulia Y. Tyurina, Valerian E. Kagan, Sally E. Wenzel
Published 2022-01-01

Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

by Tamil S. Anthonymuthu, Yulia Y. Tyurina, Wan-Yang Sun, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Vladimir A. Tyurin, Fatma B. Cinemre, Haider H. Dar, Andrew P. VanDemark, Theodore R. Holman, Yoel Sadovsky, Brent R. Stockwell, Rong-Rong He, Ivet Bahar, Hülya Bayır, Valerian E. Kagan
Published 2021-01-01

Correction: Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes and.

by Nagarjun V. Konduru, Yulia Y. Tyurina, Weihong Feng, Liana V. Basova, Natalia A. Belikova, Hülya Bayir, Katherine Clark, Marc Rubin, Donna Stolz, Helen Vallhov, Annika Scheynius, Erika Witasp, Bengt Fadeel, Padmakar D. Kichambare, Alexander Star, Elena R. Kisin, Ashley R. Murray, Anna A. Shvedova, Valerian E. Kagan
Published 2009-01-01

Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo.

by Nagarjun V Konduru, Yulia Y Tyurina, Weihong Feng, Liana V Basova, Natalia A Belikova, Hülya Bayir, Katherine Clark, Marc Rubin, Donna Stolz, Helen Vallhov, Annika Scheynius, Erika Witasp, Bengt Fadeel, Padmakar D Kichambare, Alexander Star, Elena R Kisin, Ashley R Murray, Anna A Shvedova, Valerian E Kagan
Published 2009-01-01

P. aeruginosa augments irradiation injury via 15-lipoxygenase–catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis

by Haider H. Dar, Michael W. Epperly, Vladimir A. Tyurin, Andrew A. Amoscato, Tamil S. Anthonymuthu, Austin B. Souryavong, Alexander A. Kapralov, Galina V. Shurin, Svetlana N. Samovich, Claudette M. St. Croix, Simon C. Watkins, Sally E. Wenzel, Rama K. Mallampalli, Joel S. Greenberger, Hülya Bayır, Valerian E. Kagan, Yulia Y. Tyurina
Published 2022-02-01